Multipe Sequence Alignments:
Orthology and Paralogy




  1. produce the multiple alignment and the phylogenic tree of the three following sequences in Swissprot.

    • -SCG1_HUMAN
    • -SCGA_XENLA
    • -STHM_MOUSE

  2. Discuss the results. What is wrong. Propose a strategy?
  3. Add sequences from Swiss_prot in your list, make a new multiple sequence alignment and a tree (make sure to include the SCG1 sequences from rat, human and mouse)
  4. Discuss the results and propose a new strategy in order to obtain a better tree.
  5. Note:
    • To compute the tree, use infobiogene.
    • To plot a tree, you may use phylodendron.
    • Never use a clustalw guide tree file (.dnd) in place of a phylogenetic tree.

Questions should be sent to C.Notredame