@1: Nucleotide Binding Site @2: Active Site In the active site, the Aspartic Acid is replaced with a Lysine. The kinase function is probaly not active @1 KCC1_YEAST_37_300 ----------YVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNK--VQLEALY KAPC_CAEEL_56_300 --------------KTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQ---VEHTL KAPA_RAT_47_257 --------------KTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQ---IEHTL M3K1_MOUSE_563_828 --------AEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALR SPAK_MOUSE_72_344 -------RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQT-----SMDELL z907770_150_420 DKSADDIRAAYTFARELGRGQLGVTYIVKDKSNGEFFACKSISQRKLRHTE---EREDVR PIM1_MOUSE_29_290 -KEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVP :* * . * * : KCC1_YEAST_37_300 DELDILQRLHH--PNIVAFKDWFESKDKFYIITQLAKG-GELFDRIL--------KKGKF KAPC_CAEEL_56_300 NEKRILQAIDF--PFLVNMTFSLKDNSNLYMVLEFISG-GEMFSHLR--------RIGRF KAPA_RAT_47_257 NEKRILQAVNF--PFLVKLEFSFKDNSNLYMVMEYVPG-GEMFSHLR--------RIGRF M3K1_MOUSE_563_828 EEIRMMGHLNH--PNIIRMLGATCEKSNYNLFIEWMAG-GSVAHLLS--------KYGAF SPAK_MOUSE_72_344 KEIQAMSQCSH--PNVVTYYTSFVVKDELWLVMKLLSG-GSMLDIIKYIVNRGEHKNGVL z907770_150_420 REIQIMRHLTS-QPNLVNIKGGFEDKESVHLVMELCTA-GEAFDRII--------KRGHY PIM1_MOUSE_29_290 MEVVLLKKVSSDFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT--------ERGAL * : . :: .. :. : . : . * @2 KCC1_YEAST_37_300 TEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDKSDESP-LVVADFGIAKRLKSD KAPC_CAEEL_56_300 SEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLI---DSTGY-LKVTDFGFAKRVKG- KAPA_RAT_47_257 SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLI---DQQGY-IQVTDFGFAKRVKG- M3K1_MOUSE_563_828 KESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLI---DSTGQRLRIADFGAAARLASK SPAK_MOUSE_72_344 EEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILL---GEDGS-VQIADFGVSAFLATG z907770_150_420 SERAAADIFAGIVNVVDFCHLSGVMHRKLKPENFLFLNKHEDSL-MKTTDFGVSVFIKQG PIM1_MOUSE_29_290 QEDLARGFFWQVLEAVRHCHNCGVLHRDIKDENILI--DLSRGE-IKLIDFGSGALLKD- * :: . . * ::*.:* *:* . . : *** . : KCC1_YEAST_37_300 E-----ELLYKPAGSLGYVAPEVLTQ-DGHGKPCDIWSIGVITYTLLCGYSAFRAERVQD KAPC_CAEEL_56_300 ------RTWT-LCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ KAPA_RAT_47_257 ------RTWT-LCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ M3K1_MOUSE_563_828 G-TGAGEFQGQLLGTIAFMAPEVLRG-QQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSN SPAK_MOUSE_72_344 GDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMK z907770_150_420 ------RIYTEIVGSSYYVAPEVL-Q-RSYGQELDMWSAGVIMYILLCGIPPFWAETERG PIM1_MOUSE_29_290 ------TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-- *: : .** : :. *: * : . .: