Legend:
Sequences with E-value BETTER than threshold 616 e-176
601 e-172
92 2e-18
91 3e-18
91 4e-18
90 6e-18
90 8e-18
88 3e-17
85 2e-16
82 1e-15
80 5e-15
69 1e-11
56 1e-07
56 1e-07
55 3e-07
51 3e-06
49 1e-05
48 2e-05
47 6e-05
47 8e-05
45 2e-04
44 6e-04
Sequences with E-value WORSE than threshold sp|P38630|RFC1_YEAST ACTIVATOR 1 95 KD SUBUNIT (REPLICATION FAC... 39 0.014
sp|Q08387|DNL4_YEAST DNA LIGASE II (POLYDEOXYRIBONUCLEOTIDE SYN... 39 0.019
sp|P49917|DNL4_HUMAN DNA LIGASE IV (POLYDEOXYRIBONUCLEOTIDE SYN... 38 0.042
sp|O83642|DNLJ_TREPA DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHA... 36 0.16
sp|P48754|BRC1_MOUSE BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEI... 34 0.36
sp|O14079|YEAE_SCHPO HYPOTHETICAL 58.4 KD PROTEIN C2E11.14 IN C... 34 0.62
sp|P52496|DNLI_CANAL DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHA... 33 0.81
sp|P31669|PPOL_XENLA POLY [ADP-RIBOSE] POLYMERASE (PARP) (ADPRT... 33 1.1
sp|P78021|DNLJ_MYCPN DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHA... 32 1.8
sp|Q95153|BRC1_CANFA BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEI... 32 1.8
sp|P09874|PPOL_HUMAN POLY [ADP-RIBOSE] POLYMERASE (PARP) (ADPRT... 31 4.1
sp|P26446|PPOL_CHICK POLY [ADP-RIBOSE] POLYMERASE (PARP) (ADPRT... 31 5.4
sp|P35875|PPOL_DROME POLY [ADP-RIBOSE] POLYMERASE (PARP) (ADPRT... 30 7.1
sp|Q02578|KAS1_STRCN PUTATIVE POLYKETIDE BETA-KETOACYL SYNTHASE 1 30 9.2
Alignments
sp|P18887|XRCC_HUMAN DNA-REPAIR PROTEIN XRCC1
Length = 633
Score = 616 bits (1571), Expect = e-176
Identities = 337/400 (84%), Positives = 337/400 (84%)
Query: 1 MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDI 60
MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDI
Sbjct: 1 MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDI 60
Query: 61 GNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAA 120
GNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAA
Sbjct: 61 GNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAA 120
Query: 121 AEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDE 180
AEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDE
Sbjct: 121 AEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDE 180
Query: 181 SANSLRPGALFFSRINKTSPVTASDPAGPXXXXXXXXXXXXXXXXXXXXXXIGSTSKPQE 240
SANSLRPGALFFSRINKTSPVTASDPAGP IGSTSKPQE
Sbjct: 181 SANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQASSAASSASPVSRAIGSTSKPQE 240
Query: 241 SPKGKRKLDLNQEEKKTPSKPPAQLSPSVXXXXXXXXXXXXXXXXXXXXXXQGAVTXXXX 300
SPKGKRKLDLNQEEKKTPSKPPAQLSPSV QGAVT
Sbjct: 241 SPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVPARAQGAVTGKPR 300
Query: 301 XXXXXXXXXXXXXXXLGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHL 360
LGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHL
Sbjct: 301 GEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHL 360
Query: 361 ICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRR 400
ICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRR
Sbjct: 361 ICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRR 400
Score = 31.3 bits (69), Expect = 3.1
Identities = 13/75 (17%), Positives = 24/75 (31%), Gaps = 2/75 (2%)
Query: 325 VVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLG--GRIVR 382
+ F R +L + + +I A P + + L VR
Sbjct: 549 FLYGEFPGDERRKLIRYVTAFNGELEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVR 608
Query: 383 KEWVLDCHRMRRRLP 397
W+ C+ ++ LP
Sbjct: 609 PRWIYSCNEKQKLLP 623
sp|Q60596|XRCC_MOUSE DNA-REPAIR PROTEIN XRCC1
Length = 631
Score = 601 bits (1533), Expect = e-172
Identities = 309/402 (76%), Positives = 321/402 (78%), Gaps = 4/402 (0%)
Query: 1 MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDI 60
MPEI LRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDI
Sbjct: 1 MPEISLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDI 60
Query: 61 GNDGSAFVEVLVGSSAGGA--GEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVR 118
GNDGSAFVEVLVGSSAGGA GEQDYEVLLVTSSFMSPSESRSGSNPNRVR+FGPDKLVR
Sbjct: 61 GNDGSAFVEVLVGSSAGGATAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRIFGPDKLVR 120
Query: 119 AAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEE 178
AAAEKRWDRVKIVCSQPYSKDSP+GLSFV+FHSPPDKDEAEA SQKVTVTKLGQFRVKEE
Sbjct: 121 AAAEKRWDRVKIVCSQPYSKDSPYGLSFVKFHSPPDKDEAEATSQKVTVTKLGQFRVKEE 180
Query: 179 DESANSLRPGALFFSRINKTSPVTASDPAGPXXXXXXXXXXXXXXXXXXXXXXIGSTSKP 238
D+SANSL+PGALFFSRINKTS + SDPAGP +GS+SKP
Sbjct: 181 DDSANSLKPGALFFSRINKTSSASTSDPAGPSYAAATLQASSAASSASPVPKVVGSSSKP 240
Query: 239 QESPKGKRKLDLNQEEKKTPSKPPAQLSPSVXXXXXXXXXXXXXXXXXXXXXXQGAVTXX 298
QE PKGKRKLDL+ E++K PSKP A PS Q A+
Sbjct: 241 QEPPKGKRKLDLSLEDRKPPSKPSA--GPSTLKRPKLSVPSRTPAAAPASTPAQRAIPGK 298
Query: 299 XXXXXXXXXXXXXXXXXLGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDST 358
LGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWT DST
Sbjct: 299 PRGEGTEPRGARTGPQELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTPDST 358
Query: 359 HLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRR 400
HLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRR
Sbjct: 359 HLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSRR 400
Score = 30.9 bits (68), Expect = 4.1
Identities = 13/75 (17%), Positives = 22/75 (29%), Gaps = 2/75 (2%)
Query: 325 VVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLG--GRIVR 382
+ F R L + +I A P + + L VR
Sbjct: 547 FLYGEFPGDERRRLIRYVTAFNGELEDYMNERVQFVITAQEWDPNFEEALMENPSLAFVR 606
Query: 383 KEWVLDCHRMRRRLP 397
W+ C+ ++ LP
Sbjct: 607 PRWIYSCNEKQKLLP 621
sp|P49422|DNLJ_THESC DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 674
Score = 92.1 bits (225), Expect = 2e-18
Identities = 18/80 (22%), Positives = 35/80 (43%)
Query: 318 KILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLG 377
+ L+G+ V++G + R E++ LGAK +R +++L+ K + LG
Sbjct: 589 EALKGLTFVITGELSRPREEVKALLRRLGAKVTDSVSRKTSYLVVGENPGSKLEKARALG 648
Query: 378 GRIVRKEWVLDCHRMRRRLP 397
+ +E + R P
Sbjct: 649 VPTLTEEELYRLIEERTGKP 668
sp|P32372|RAD4_SCHPO RAD4 PROTEIN (CUT5 PROTEIN) (P74)
Length = 648
Score = 91.3 bits (223), Expect = 3e-18
Identities = 27/71 (38%), Positives = 39/71 (54%), Gaps = 2/71 (2%)
Query: 318 KILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGL- 376
K L+G V+ + R+E+ KA +LGA YR D+T+D THLI +TPKY
Sbjct: 5 KPLKGFVICCTSIDLKQRTEISTKATKLGAAYRSDFTKDVTHLIAGDFDTPKYKFAAKSR 64
Query: 377 -GGRIVRKEWV 386
+I+ EW+
Sbjct: 65 PDIKIMSSEWI 75
Score = 68.7 bits (165), Expect = 2e-11
Identities = 23/74 (31%), Positives = 33/74 (44%)
Query: 323 VVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVR 382
V L+ P RS + + L+ G + PD TRD THLI ++ KY L +V
Sbjct: 105 CRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVC 164
Query: 383 KEWVLDCHRMRRRL 396
EW+ + L
Sbjct: 165 VEWLWQSIQRNAVL 178
sp|P12689|REV1_YEAST DNA REPAIR PROTEIN REV1
Length = 985
Score = 90.9 bits (222), Expect = 4e-18
Identities = 19/82 (23%), Positives = 40/82 (48%), Gaps = 4/82 (4%)
Query: 318 KILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDW--TRDSTHLICAFANTPKYSQVLG 375
KI + V+ ++G+ P R +L + + G K+ + TH++ + N P ++
Sbjct: 164 KIFKNCVIYINGYTKPGRLQLHEMIVLHGGKFLHYLSSKKTVTHIVAS--NLPLKKRIEF 221
Query: 376 LGGRIVRKEWVLDCHRMRRRLP 397
++V +W++D + R LP
Sbjct: 222 ANYKVVSPDWIVDSVKEARLLP 243
sp|O74161|CHS5_CANAL CHITIN BIOSYNTHESIS PROTEIN CHS5
Length = 562
Score = 90.1 bits (220), Expect = 6e-18
Identities = 27/82 (32%), Positives = 41/82 (49%), Gaps = 7/82 (8%)
Query: 320 LQGVVVVLSGFQ--NPFRSELRDKALE-LGAKY--RPDWTRDSTHLICAFAN--TPKYSQ 372
L G+ V L + F E ++AL+ +GAKY + D+TH +C N P+Y +
Sbjct: 169 LSGITVCLGDLTPNDQFNKEDIEEALKNMGAKYPVQQQVKVDTTHFLCTRENKQNPEYVK 228
Query: 373 VLGLGGRIVRKEWVLDCHRMRR 394
+ I+R EW+ C R RR
Sbjct: 229 ANDMNIPIIRPEWLKACERERR 250
sp|Q07139|ECT2_MOUSE ECT2 PROTEIN (ECT2 ONCOGENE)
Length = 738
Score = 89.7 bits (219), Expect = 8e-18
Identities = 16/73 (21%), Positives = 29/73 (38%), Gaps = 1/73 (1%)
Query: 322 GVVVVLSGFQNPFR-SELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRI 380
+V+ +GF+ +L +G R + THL+ K+ + LG I
Sbjct: 3 NLVLCFTGFRKKEELVKLVTLVHHMGGVIRKECNSKVTHLVANCTQGEKFRVAVSLGTPI 62
Query: 381 VRKEWVLDCHRMR 393
++ EW+ R
Sbjct: 63 MKPEWIYKAWERR 75
sp|P26996|DNLJ_THETH DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 676
Score = 87.8 bits (214), Expect = 3e-17
Identities = 18/80 (22%), Positives = 35/80 (43%)
Query: 317 GKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGL 376
G+ L+G+ V++G + R E++ LGAK +R +++L+ K + L
Sbjct: 591 GEALKGLTFVITGELSRPREEVKALLRRLGAKVTDSVSRKTSYLVVGENPGSKLEKARAL 650
Query: 377 GGRIVRKEWVLDCHRMRRRL 396
G + +E + R
Sbjct: 651 GVPTLTEEELYRLLEARTGK 670
sp|Q92357|CHS5_SCHPO PROBABLE CHITIN BIOSYNTHESIS PROTEIN C6G9.12 (CHS5 HOMOLOG)
Length = 620
Score = 85.5 bits (208), Expect = 2e-16
Identities = 18/78 (23%), Positives = 30/78 (38%), Gaps = 3/78 (3%)
Query: 320 LQGVVVVLSGFQNPFRSELRDKALE--LGAKYRPDWTRDSTHLICAFANTPKYSQVLGLG 377
L G+ V + P E K +E + D+TH IC+ P+Y +
Sbjct: 172 LTGIQVCVGNM-VPNEMEALQKCIERIHARPIQTSVRIDTTHFICSSTGGPEYEKAKAAN 230
Query: 378 GRIVRKEWVLDCHRMRRR 395
I+ +++L C R
Sbjct: 231 IPILGLDYLLKCESEGRL 248
sp|Q10337|YD97_SCHPO HYPOTHETICAL 98.4 KD PROTEIN C19G10.07 IN CHROMOSOME I
Length = 878
Score = 82.3 bits (200), Expect = 1e-15
Identities = 17/70 (24%), Positives = 26/70 (36%)
Query: 320 LQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGR 379
L+ +V ++ + + R L L GA Y D +T LI A + KY
Sbjct: 316 LKDQMVAVTNYTDAARIYLEKLLLACGATYTKDLKPTNTLLIAASSYGQKYGAAKVWNIP 375
Query: 380 IVRKEWVLDC 389
V W+
Sbjct: 376 TVHHSWLYSS 385
Score = 36.8 bits (83), Expect = 0.072
Identities = 15/73 (20%), Positives = 28/73 (37%), Gaps = 3/73 (4%)
Query: 320 LQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLG---L 376
+G+ + S + D G ++ + THL K +VL L
Sbjct: 110 FKGICASSCQIDSYQSSLIDDALETFGGRFSKGLMKSMTHLFTYSGMGAKCKKVLDKPSL 169
Query: 377 GGRIVRKEWVLDC 389
+++ +W+LDC
Sbjct: 170 SIKLIHPQWLLDC 182
Score = 32.9 bits (73), Expect = 1.1
Identities = 14/68 (20%), Positives = 27/68 (39%), Gaps = 4/68 (5%)
Query: 332 NPFRSELRDKALELGAK---YRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLD 388
N ++ ++ K + DW +TH+IC ++P + R+ + W+ D
Sbjct: 31 NQNELRKKELFIKNDGKALSFPYDWKL-ATHVICDDFSSPNVQEGSKRSLRLAKTNWIRD 89
Query: 389 CHRMRRRL 396
C L
Sbjct: 90 CVDKNTLL 97
sp|Q12114|CHS5_YEAST CHITIN BIOSYNTHESIS PROTEIN CHS5 (CAL3 PROTEIN)
Length = 671
Score = 80.4 bits (195), Expect = 5e-15
Identities = 19/85 (22%), Positives = 32/85 (37%), Gaps = 12/85 (14%)
Query: 320 LQGVVVVLSGFQNPFRSELRDKAL-----ELGAK-YRPDWTRDSTHLICAFANTPK---- 369
+ G+ V L E+ D + +GA+ + D+TH +C + +
Sbjct: 171 MSGITVCLGPLDPL--KEISDLQISQCLSHIGARPLQRHVAIDTTHFVCNDLDNEESNEE 228
Query: 370 YSQVLGLGGRIVRKEWVLDCHRMRR 394
+ IVR EWV C +R
Sbjct: 229 LIRAKHNNIPIVRPEWVRACEVEKR 253
sp|P47027|YJJ0_YEAST HYPOTHETICAL 87.2 KD PROTEIN IN SRS2-SIP4 INTERGENIC REGION
Length = 764
Score = 69.5 bits (167), Expect = 1e-11
Identities = 15/66 (22%), Positives = 26/66 (38%), Gaps = 2/66 (3%)
Query: 318 KILQGVVVVLSGFQNP-FRSELRDKALELGAKYRPDWTRDSTHLICAF-ANTPKYSQVLG 375
K QG+ + N ++ K ++LG + D TR L+ NT K+ +
Sbjct: 2 KPFQGITFCPTAINNEILAKKISKKIIKLGGIFSKDLTRQVNVLVVGSTTNTNKFKFAVK 61
Query: 376 LGGRIV 381
I+
Sbjct: 62 HRFDII 67
Score = 35.2 bits (79), Expect = 0.21
Identities = 8/38 (21%), Positives = 15/38 (39%)
Query: 360 LICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLP 397
+ + + + IV +W+LDC + LP
Sbjct: 177 FVTDTLLGARVNAAIEQNIPIVHFKWILDCQKRSALLP 214
sp|P49421|DNLJ_RHOMR DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 712
Score = 55.9 bits (132), Expect = 1e-07
Identities = 14/76 (18%), Positives = 32/76 (41%), Gaps = 1/76 (1%)
Query: 319 ILQGVVVVLSGFQNPF-RSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLG 377
++G VL+G R E + G + +R++ +++ KY + LG
Sbjct: 637 PVRGKTFVLTGALPHLTRKEAEELIKRAGGRVASSVSRNTDYVVVGENPGSKYDRARQLG 696
Query: 378 GRIVRKEWVLDCHRMR 393
++ ++ +L M+
Sbjct: 697 IPMLDEDGLLRLLGMK 712
sp|O25336|DNLJ_HELPY DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 656
Score = 55.9 bits (132), Expect = 1e-07
Identities = 15/73 (20%), Positives = 26/73 (35%)
Query: 320 LQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGR 379
+VL+G + R E LGAK + + LI K + G
Sbjct: 582 FNNKTIVLTGTLSKPRQEYAQMLENLGAKISSSVSAKTDFLIAGENPGSKLALAQKHGVS 641
Query: 380 IVRKEWVLDCHRM 392
++ +E +L +
Sbjct: 642 VLNEEELLKRLKE 654
sp|P35600|GNF1_DROME GERMLINE TRANSCRIPTION FACTOR 1
Length = 986
Score = 54.7 bits (129), Expect = 3e-07
Identities = 16/78 (20%), Positives = 30/78 (37%), Gaps = 2/78 (2%)
Query: 320 LQGVVVVLSG-FQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTP-KYSQVLGLG 377
L G+ V++G ++ R E E G K + +L+ P K + L
Sbjct: 237 LSGLTFVVTGVLESMEREEAESVIKEYGGKVMTVVGKKLKYLVVGEEAGPKKLAVAEELN 296
Query: 378 GRIVRKEWVLDCHRMRRR 395
I+ ++ + D R +
Sbjct: 297 IPILSEDGLFDLIREKSG 314
sp|P35601|AC15_MOUSE ACTIVATOR 1 140 KD SUBUNIT (REPLICATION FACTOR C LARGE SUBUNIT) (A1
140 KD SUBUNIT) (RF-C 140 KD SUBUNIT) (ACTIVATOR 1 LARGE
SUBUNIT) (A1-P145) (DIFFERENTIATION SPECIFIC ELEMENT
BINDING PROTEIN) (ISRE-BINDING PROTEIN)
Length = 1131
Score = 51.2 bits (120), Expect = 3e-06
Identities = 17/82 (20%), Positives = 36/82 (43%), Gaps = 2/82 (2%)
Query: 320 LQGVVVVLSGFQNP-FRSELRDKALELGAKYRPDWTRDSTHLICAFANT-PKYSQVLGLG 377
L+G+ V++G R E + G K + ++ + +L+ + K + LG
Sbjct: 404 LEGLTFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALG 463
Query: 378 GRIVRKEWVLDCHRMRRRLPSR 399
+I+ ++ +LD R S+
Sbjct: 464 TKILDEDGLLDLIRTMPGKRSK 485
sp|P43813|DNLJ_HAEIN DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 679
Score = 49.2 bits (115), Expect = 1e-05
Identities = 16/70 (22%), Positives = 29/70 (40%), Gaps = 1/70 (1%)
Query: 320 LQGVVVVLSG-FQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGG 378
+ VVL+G R+E + +LGAK + + +I A K ++ L
Sbjct: 606 FKDKTVVLTGTLTQMGRNEAKALLQQLGAKVSGSVSSKTDFVIAGDAAGSKLAKAQELNI 665
Query: 379 RIVRKEWVLD 388
++ +E L
Sbjct: 666 TVLTEEEFLA 675
sp|P35251|AC15_HUMAN ACTIVATOR 1 140 KD SUBUNIT (REPLICATION FACTOR C LARGE SUBUNIT) (A1
140 KD SUBUNIT) (RF-C 140 KD SUBUNIT) (ACTIVATOR 1 LARGE
SUBUNIT) (DNA-BINDING PROTEIN PO-GA)
Length = 1147
Score = 48.5 bits (113), Expect = 2e-05
Identities = 16/82 (19%), Positives = 37/82 (44%), Gaps = 2/82 (2%)
Query: 320 LQGVVVVLSGFQNP-FRSELRDKALELGAKYRPDWTRDSTHLICAFANT-PKYSQVLGLG 377
L+G++ V++G R E + G K + ++ + +L+ + K + LG
Sbjct: 407 LEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALG 466
Query: 378 GRIVRKEWVLDCHRMRRRLPSR 399
+I+ ++ +L+ R S+
Sbjct: 467 TKIIDEDGLLNLIRTMPGKKSK 488
sp|P28719|DNLJ_ZYMMO DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 731
Score = 46.9 bits (109), Expect = 6e-05
Identities = 17/67 (25%), Positives = 31/67 (45%), Gaps = 1/67 (1%)
Query: 319 ILQGVVVVLSG-FQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLG 377
L G ++V +G Q R E + +A LGAK ++ + ++ A K S+ L
Sbjct: 649 PLSGKIIVFTGSLQKITRDEAKRQAENLGAKVASSVSKKTNLVVAGEAAGSKLSKAKELD 708
Query: 378 GRIVRKE 384
I+ ++
Sbjct: 709 ISIIDED 715
sp|P38850|YHV4_YEAST HYPOTHETICAL 123.0 KD PROTEIN IN SPO16-REC104 INTERGENIC REGION
Length = 1070
Score = 46.5 bits (108), Expect = 8e-05
Identities = 14/75 (18%), Positives = 25/75 (32%), Gaps = 6/75 (8%)
Query: 321 QGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGR- 379
+ + V + + R ++ LG P+ TR +THLI K+
Sbjct: 378 KELTVAYTNYFGSQRFYIQRLVEILGGLSTPELTRKNTHLITKSTIGKKFKVAKKWSLDP 437
Query: 380 -----IVRKEWVLDC 389
+ W+ C
Sbjct: 438 QNAIIVTNHMWLEQC 452
Score = 30.1 bits (66), Expect = 7.1
Identities = 12/44 (27%), Positives = 18/44 (40%), Gaps = 2/44 (4%)
Query: 355 RDSTHLICAFA-NTPKYSQVLG-LGGRIVRKEWVLDCHRMRRRL 396
+ H + + N P Y V L +V WV D + +R L
Sbjct: 66 PQTVHFVISNTINFPFYKIVYFDLLIPVVSHTWVQDSVKTKRHL 109
sp|P15042|DNLJ_ECOLI DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 671
Score = 45.0 bits (104), Expect = 2e-04
Identities = 17/74 (22%), Positives = 34/74 (44%), Gaps = 1/74 (1%)
Query: 316 LGKILQGVVVVLSGFQNPF-RSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVL 374
+ G VVL+G + R + + + +ELGAK ++ + +I A K ++
Sbjct: 594 IDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQ 653
Query: 375 GLGGRIVRKEWVLD 388
LG ++ + +L
Sbjct: 654 ELGIEVIDEAEMLR 667
sp|Q03254|YM8K_YEAST HYPOTHETICAL 83.4 KD PROTEIN IN DSK2-CAT8 INTERGENIC REGION
Length = 732
Score = 43.8 bits (101), Expect = 6e-04
Identities = 21/78 (26%), Positives = 31/78 (38%), Gaps = 6/78 (7%)
Query: 318 KILQGVVVVLSGF----QNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQV 373
K+ Q V SG + RS++ GA PD +THLI +T K
Sbjct: 502 KVFQNCYFVFSGLIPLGTDIQRSDIVIWTSTFGATSTPDIDYLTTHLITKNPSTYKARLA 561
Query: 374 LGLG--GRIVRKEWVLDC 389
+IV +W+ +C
Sbjct: 562 KKFNPQIKIVHPDWIFEC 579
sp|P38630|RFC1_YEAST ACTIVATOR 1 95 KD SUBUNIT (REPLICATION FACTOR C 95 KD SUBUNIT)
(CELL DIVISION CONTROL PROTEIN 44)
Length = 861
Score = 39.1 bits (89), Expect = 0.014
Identities = 13/72 (18%), Positives = 28/72 (38%), Gaps = 4/72 (5%)
Query: 317 GKI--LQGVVVVLSGFQNPFRSELRD-KALELGAKYRPDWTRDSTHLICAFANTP-KYSQ 372
GK L G+ +V +G + A GA+ + ++ ++ P K +
Sbjct: 153 GKPNCLLGLTIVFTGVLPTLERGASEALAKRYGARVTKSISSKTSVVVLGDEAGPKKLEK 212
Query: 373 VLGLGGRIVRKE 384
+ L + + +E
Sbjct: 213 IKQLKIKAIDEE 224
sp|Q08387|DNL4_YEAST DNA LIGASE II (POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP)) (DNA LIGASE
IV HOMOLOG)
Length = 944
Score = 38.7 bits (88), Expect = 0.019
Identities = 18/92 (19%), Positives = 35/92 (37%), Gaps = 13/92 (14%)
Query: 316 LGKILQGVVVVL--------SGFQNPFRSELRDKALELGAKYRPDWTRDSTHL----ICA 363
+ I G++ + +G + R+EL +E G K + + + +
Sbjct: 682 ISNIFAGLLFYVLSDYVTEDTGIRIT-RAELEKTIVEHGGKLIYNVILKRHSIGDVRLIS 740
Query: 364 FANTPKYSQVLGLGGRIVRKEWVLDCHRMRRR 395
T + ++ G I+ WVLDC +R
Sbjct: 741 CKTTTECKALIDRGYDILHPNWVLDCIAYKRL 772
sp|P49917|DNL4_HUMAN DNA LIGASE IV (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
Length = 844
Score = 37.6 bits (85), Expect = 0.042
Identities = 16/83 (19%), Positives = 36/83 (43%), Gaps = 1/83 (1%)
Query: 316 LGKILQGVVVVL-SGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVL 374
+ I + V + SG + + +L ++ E G + D+ +I N + +L
Sbjct: 588 ISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIIL 647
Query: 375 GLGGRIVRKEWVLDCHRMRRRLP 397
+V+ W+L+C + + +P
Sbjct: 648 SNKHDVVKPAWLLECFKTKSFVP 670
sp|O83642|DNLJ_TREPA DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 823
Score = 35.6 bits (80), Expect = 0.16
Identities = 16/73 (21%), Positives = 28/73 (37%), Gaps = 2/73 (2%)
Query: 319 ILQGVVVVLSGF-QNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLG 377
LQG SG ++ ++K LG T +L+ +T +Y LG
Sbjct: 658 PLQGKSFYFSGASRSMNHKHAQEKVRALGGDVASSVTAQLDYLVFYSQST-RYRTACALG 716
Query: 378 GRIVRKEWVLDCH 390
+I+ +E +
Sbjct: 717 IQIISEETLHKLI 729
Score = 35.2 bits (79), Expect = 0.21
Identities = 13/68 (19%), Positives = 24/68 (35%), Gaps = 3/68 (4%)
Query: 319 ILQGVVVVLSG-FQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTP--KYSQVLG 375
L G+ SG R++ LG + + T+L+ + K +
Sbjct: 745 PLHGMSFCFSGDLDGMTRAQAIALVQRLGGTVKTAVSTQLTYLVSNDPHGQSRKCQNAVR 804
Query: 376 LGGRIVRK 383
G RI+ +
Sbjct: 805 CGVRIISE 812
Score = 34.8 bits (78), Expect = 0.28
Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 5/71 (7%)
Query: 319 ILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTP-----KYSQV 373
L+G SG + LG R TRD ++LI + P K +
Sbjct: 566 PLRGKSFCFSGSLRNGDRATIHRIRALGGVVRTSVTRDLSYLIFESLSQPYRTAQKLKKE 625
Query: 374 LGLGGRIVRKE 384
G+ I+ ++
Sbjct: 626 QGVALEIISED 636
sp|P48754|BRC1_MOUSE BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN HOMOLOG
Length = 1812
Score = 34.4 bits (77), Expect = 0.36
Identities = 19/81 (23%), Positives = 31/81 (37%), Gaps = 6/81 (7%)
Query: 322 GVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICA------FANTPKYSQVLG 375
+ +V+SG ++ A + T ++TH+I T KY +
Sbjct: 1592 DISMVVSGLTPKEVMTVQKFAEKYRLTLTDAITEETTHVIIKTDAEFVCERTLKYFLGIA 1651
Query: 376 LGGRIVRKEWVLDCHRMRRRL 396
G IV WV+ + RR L
Sbjct: 1652 GGKWIVSYSWVVRSIQERRLL 1672
Score = 31.7 bits (70), Expect = 2.4
Identities = 24/90 (26%), Positives = 35/90 (38%), Gaps = 15/90 (16%)
Query: 318 KILQGVVV-VLSGFQNPFRSELRDKALELGA---KYRPDWTRDS-THLIC--------AF 364
K+ +G+ V F N + +L GA K P T D+ HL+
Sbjct: 1701 KLFKGLQVYCCDPFTNMPKDDLERMLQLCGASVVKELPSLTHDTGAHLVVIVQPSAWTED 1760
Query: 365 ANTPKYSQVLGLGGRIVRKEWVLDCHRMRR 394
+N P Q+ R+V +WVLD R
Sbjct: 1761 SNCPDIGQLCKA--RLVMWDWVLDSLSSYR 1788
sp|O14079|YEAE_SCHPO HYPOTHETICAL 58.4 KD PROTEIN C2E11.14 IN CHROMOSOME I
Length = 520
Score = 33.7 bits (75), Expect = 0.62
Identities = 12/61 (19%), Positives = 24/61 (38%), Gaps = 3/61 (4%)
Query: 342 ALELGAKYRPDWTRDSTHLICAFAN---TPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPS 398
G + + T ++ +I T K+ LG +V +++ DC + + L
Sbjct: 300 IRRNGLRVQESVTDETDFVILGSPPLRRTHKFLLATSLGIPLVSSQYLTDCIKSGKVLDF 359
Query: 399 R 399
R
Sbjct: 360 R 360
sp|P52496|DNLI_CANAL DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP])
Length = 864
Score = 33.3 bits (74), Expect = 0.81
Identities = 11/60 (18%), Positives = 23/60 (38%), Gaps = 2/60 (3%)
Query: 336 SELRDKALELGAKYRPDWTRDSTH--LICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMR 393
E++ + G K + + ++ P SQ L G +V+ W+ +C +
Sbjct: 700 EEMKAMVKQYGGKIVNSVDLATNYQIMVITERELPVSSQYLSKGIDLVKPIWIYECIKRG 759
sp|P31669|PPOL_XENLA POLY [ADP-RIBOSE] POLYMERASE (PARP) (ADPRT) (NAD(+)
ADP-RIBOSYLTRANSFERASE) (POLY[ADP-RIBOSE] SYNTHETASE)
Length = 998
Score = 32.9 bits (73), Expect = 1.1
Identities = 16/80 (20%), Positives = 30/80 (37%), Gaps = 9/80 (11%)
Query: 317 GKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTP------KY 370
GK L V+L G + + E++ LG K + + +C N K
Sbjct: 371 GKPLTNTKVLLIGKLSKNKDEVKTLIEGLGGKVAGSAHKAN---LCISTNKEVKKMSKKM 427
Query: 371 SQVLGLGGRIVRKEWVLDCH 390
+V R+V +++ +
Sbjct: 428 EEVKAANVRVVSDDFLKEVE 447
sp|P78021|DNLJ_MYCPN DNA LIGASE (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])
Length = 658
Score = 32.1 bits (71), Expect = 1.8
Identities = 10/61 (16%), Positives = 24/61 (38%), Gaps = 2/61 (3%)
Query: 325 VVLSGFQNPFRSELRDKAL-ELGAKYRPDWTRDSTHLICAFANTP-KYSQVLGLGGRIVR 382
V++G R +++ + + ++ + T ++ TP K Q L I+
Sbjct: 594 FVITGSFPISRDTIKNLLVNKYDCRFTNNVTSKVDFVLAGIKATPRKLEQAKALNIPIIN 653
Query: 383 K 383
+
Sbjct: 654 E 654
sp|Q95153|BRC1_CANFA BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN HOMOLOG
Length = 1878
Score = 32.1 bits (71), Expect = 1.8
Identities = 16/84 (19%), Positives = 25/84 (29%), Gaps = 11/84 (13%)
Query: 318 KILQGVVVVL-SGFQNPFRSELRDKALELGAKYRPDWT----RDSTHLICAFANTPKYSQ 372
KI +G+ + F N +L GA + + TH +
Sbjct: 1767 KIFRGLEICCYGPFTNMPTDQLEWMVHLCGASVVKEPSLFTLSKGTHPVVVVQPDAWTED 1826
Query: 373 VLGLGG------RIVRKEWVLDCH 390
+V +EWVLD
Sbjct: 1827 SGFHAIGQMCEAPVVTREWVLDSV 1850
sp|P09874|PPOL_HUMAN POLY [ADP-RIBOSE] POLYMERASE (PARP) (ADPRT) (NAD(+)
ADP-RIBOSYLTRANSFERASE) (POLY[ADP-RIBOSE] SYNTHETASE)
Length = 1014
Score = 30.9 bits (68), Expect = 4.1
Identities = 14/77 (18%), Positives = 30/77 (38%), Gaps = 9/77 (11%)
Query: 318 KILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFAN------TPKYS 371
K L + ++ G + + E++ +LG K + S +C K
Sbjct: 388 KPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKAS---LCISTKKEVEKMNKKME 444
Query: 372 QVLGLGGRIVRKEWVLD 388
+V R+V ++++ D
Sbjct: 445 EVKEANIRVVSEDFLQD 461
sp|P26446|PPOL_CHICK POLY [ADP-RIBOSE] POLYMERASE (PARP) (ADPRT) (NAD(+)
ADP-RIBOSYLTRANSFERASE) (POLY[ADP-RIBOSE] SYNTHETASE)
Length = 1011
Score = 30.5 bits (67), Expect = 5.4
Identities = 15/77 (19%), Positives = 31/77 (39%), Gaps = 9/77 (11%)
Query: 318 KILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTP------KYS 371
K L + ++ G + + E+++ ELG K + + +C K
Sbjct: 385 KPLTNMKILTLGKLSKNKEEVKNIVEELGGKMTTTANKAT---LCISTQKEVEKMSKKME 441
Query: 372 QVLGLGGRIVRKEWVLD 388
+V R+V +E++ D
Sbjct: 442 EVKDAKVRVVSEEFLKD 458
sp|P35875|PPOL_DROME POLY [ADP-RIBOSE] POLYMERASE (PARP) (ADPRT) (NAD(+)
ADP-RIBOSYLTRANSFERASE) (POLY[ADP-RIBOSE] SYNTHETASE)
Length = 994
Score = 30.1 bits (66), Expect = 7.1
Identities = 16/75 (21%), Positives = 28/75 (37%), Gaps = 5/75 (6%)
Query: 316 LGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKY----S 371
+ L + + G +N ELR + LG K+ + ++ +I K
Sbjct: 381 ISPPLYNLKFSIIGLKNQ-HKELRKRIENLGGKFEVKISENTIAIISTELEIQKKSTRMK 439
Query: 372 QVLGLGGRIVRKEWV 386
LG IV E++
Sbjct: 440 FAEELGIHIVPIEFL 454
sp|Q02578|KAS1_STRCN PUTATIVE POLYKETIDE BETA-KETOACYL SYNTHASE 1
Length = 422
Score = 29.8 bits (65), Expect = 9.2
Identities = 17/66 (25%), Positives = 28/66 (41%)
Query: 58 VDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLV 117
+D G + V V +GS+ GG +++ +LV+ + P R F P L
Sbjct: 90 IDFGTENPWRVAVSLGSAVGGTTRLEHDYVLVSERGQRWDVDHRAAEPELHRAFSPSTLA 149
Query: 118 RAAAEK 123
AE+
Sbjct: 150 ADVAER 155
CPU time: 8.90 user secs. 0.33 sys. secs 9.23 total secs.
Database: Non-redundant SwissProt sequences
Posted date: Oct 22, 1999 6:17 PM
Number of letters in database: 28,562,440
Number of sequences in database: 79,219
Lambda K H
0.318 0.131 0.401
Gapped
Lambda K H
0.270 0.0460 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17539635
Number of Sequences: 79219
Number of extensions: 597720
Number of successful extensions: 1133
Number of sequences better than 10.0: 48
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1050
Number of HSP's gapped (non-prelim): 72
length of query: 400
length of database: 28562440
effective HSP length: 54
effective length of query: 346
effective length of database: 24284614
effective search space: 8402476444
effective search space used: 8402476444
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.2 bits)
S2: 65 (29.8 bits)
