Beyond the limit of the traditional ("bourgeois") domain shuffling view: some alternative ("situationist") protein evolution models

Jean-Michel Claverie,IGS

Situationism began in the late nineteen fifties as a Surrealist inspired attack on the mechanism of alienated consumption and the vulgar values of The Society of the Spectacle, the title of a work by Guy Debord, where much of the Situationist ideas are conveyed. The Situationists critiqued the idea of work, play, the media, all organisation, all hierarchy, and the traditional Left, emphasizing spontaneous self-expression, sexual liberation, the necessity for creativity and the exaltation of imagination and desire. Just as the spectacle must change all the time, to give the illusion of motion, so too must Situationism, to be able to challenge its domination.

Just as the traditional view of protein evolution give the illusion of change, alternative models are necessary to account for real protein creativity.

Relevant bibliography:
Ogata H., Audic S., Barbe V., Artiguenave F., Fournier P.-E., Raoult D. and Claverie J.-M. (2000)Selfish DNA in Protein Coding Genes of Rickettsia.Science 290 : 347-350.
Abergel C., Robertson D.L. and Claverie J.-M. (1999) "Hidden" dUTPase sequence in HIV-1 gp120 J. Virol. 73 : 751-753