Notredame's Lab
Comparative Bioinformatics


GROUP SERVERS T-COFFEE RESEARCH TEACHING CONTACT DOWNLOADS JOBS



WELCOME!

Welcome to the Comparative Bionformatics Group Homepage(aka Notredame's lab) a research group of the Center for Genomic Regulation in Barcelona. The main focus of our group is the development of novel algorithms for the comparison of multiple biological sequences. Multiple comparisons have the advantage of precisely revealing evolutionary traces, thus allowing the identification of functional constraints imposed on the evolution of biological entities. Most comparisons are currently carried out on the basis of sequence similarity. Our goal is to extend this scope by allowing comparisons based on any relevant biological signal such as sequence homology, structural similarity, genomic structure, functional similarity and more generally any signal that may be identified within biological sequences. Using such heterogeneous signals serves two complementary purposes: (i) producing better models that take advantage of the signal evolutionary resilience, (ii) improving our understanding of the evolutionary processes that lead to the diversification of biological functions. All the applications related to our work are provided to the community through an international network of web servers that can be accessed from server.tcoffee.org.




RESEARCH PROJECTS


T-Coffee A Multiple Sequence Alignment Package homepage ppt server

TCS Evaluation and filtering of multiple Sequence Alignments homepage ppt server

M-Coffee Combination of Multiple Sequence Alignment Packages homepage ppt server

3D-Coffee/Expresso Combination of Sequences and Structures homepage ppt server

R-Coffee RNA Multiple Sequence Alignment homepage ppt server

Sara-Coffee RNA Multiple Sequence Alignment Using Structural Information homepage

T-RMSD T-RMSD Structure based clustering homepage ppt  

MOCCA Repeat Discovery with T-Coffee homepage

SAGA and Coffee Multiple Protein Alignment by Genetic Algorithm homepage ppt

(P)RAGA RNA Alignment by Genetic Algorithm homepage ppt

Blast-R Fast and accurate database searches for non-coding RNAs homepage  

Strike A sequence alignment scoring tool homepage  

Pro-Coffee Aligns homologous promoter regions homepage  

Nextflow Toolkit for data-driven highly scalable pipelines homepage  



TEACHING

Courses and Lectures [web]
Workshops [web]

PUBLICATIONS

The Medline list of the lab's publications is available on [Medline].
Some of our papers are available as [PDF preprints]
My PhD [ps] [pdf]



LINKS

T-Coffee Multiple Sequence Alignments Online
Github Repository where you can download T-Coffee source code
Alignment Links Structure and Sequence Alignment Packages
Books My Favorite Scientific Books
Dummies Bioinformatics For Dummies Links
Trees THE site for phylogeny
EMBnet Online Tools at the Swiss EMBnet
ExPasy SwissProt Home

CONTACT




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Dr. Cedric Notredame, PhD.
Group Leader
Comparative Bioinformatics Group
Bioinformatics and Genomics Programme
Center for Genomic Regulation (CRG)
Dr Aiguader, 88
08003 Barcelona
Spain
Email: cedric.notredame@europe.com
HOME : http://www.tcoffee.org/homepage.html
GROUP: CRG
Phone : +34 933 160 271
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GROUP SERVERS T-COFFEE RESEARCH TEACHING CONTACT DOWNLOADS JOBS